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Pioneering AAV-Delivered T-Cell Immunotherapy To
Transform
the Treatment
Of Cancer

About Vironexis

Realizing the Full Potential of T-cell Immunotherapy

T-cell and other immunotherapies have represented a major medical advance for certain types of cancer. However, existing technologies are associated with various shortcomings that translate to safety and efficacy challenges, burdensome treatment regimens, and an impracticality of scaling customized therapies for large patient populations.

Our AAV-delivered T-cell Immunotherapy builds on the power of T-cell immunotherapy while leveraging AAV delivery to overcome the shortcomings and challenges of existing approaches. We aim to revolutionize the immunotherapy landscape and transform the treatment of cancer.

Off-the-shelf, single-dose AAV gene therapy enables durable T-cell-mediated tumor killing

With our TransJoin™ AAV Gene Therapy Platform, we are creating off-the-shelf T-cell immuno-gene therapies delivered via a one-time infusion and without the need for pre-treatment or custom-manufacturing.

TransJoin enables the expression of an engineered transgene that redirects T cells throughout the body to tumor cells and provides a bridge that joins them together, promoting steady-state, durable T-cell-mediated tumor killing.


About Vironexis

Pipeline

We’re working to quickly advance important treatment options for patients. To date, we’ve built a pipeline of 10+ product candidates for blood-based cancers, solid tumor metastasis prevention, and cancer prevention through a vaccine.

Programs
Indication
Target
Preclinical
Clinical
Discovery
IND-Enabling
Phase 1/2
Phase 2/3
Upcoming Milestones

Pillar 1 – Blood Based Cancer

Discovery
IND-Enabling
Phase 1/2
Phase 2/3

VNX-101

Acute Lymphoblastic Leukemia
CD19
FDA Fast Track Designation FDA Rare Pediatrics Designation
Upcoming Milestones
4Q 2024
First Patient Dosed
IND
4Q 2024
First Patient Dosed

VNX-102

Multiple Myeloma
BCMA/GPRC5D
Upcoming Milestones
2025
IND-Enabling Studies
2025
IND-Enabling Studies

VNX-103

B-cell Lymphoma
CD19/20

Pillar 2 – Solid Tumors

VNX-201

Neuroblastoma
GD2

VNX-202

Breast Cancer
HER2
Upcoming Milestones
Mid 2025
IND Submision
Mid 2025
IND Submision

VNX-203

Gastric Cancer
Gastric Cancer

VNX-204

Pancreatic Cancer
PSMA

VNX-205

Prostate Cancer
MSLN

VNX-206

Osteosarcoma
B7H3

VNX-207

Nasopharyngeal Cancer
GP350

VNX-208

Non-Small Cell Lung Cancer

Pillar 3 – Cancer Prevention

VNX-301

Nasopharyngeal Cancer
GP350

Partner Programs

VNX-101-2*

Systemic Lupus Erythematosus
CD19

*Vironexis plans to partner this program for further development.

Visionary
Gene therapy & Oncology Pioneers

Brian Kaspar headshot
Samit Varma headshot

Our founding team has deep expertise in successful gene therapy development, cutting-edge oncology research, and company formation. We’ve combined our know-how to change the paradigm in cancer treatment outcomes.


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